Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 77 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
â€
Top Medical Research Studies
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
9
Reduced headaches
224 people found this helpful
This supplement aids in the correct transmission of nerve impulses in the body. Choline and inositol are essential B vitamins necessary for brain, nervous system health, and fatty acid metabolism. I combine these with True Calm and have found noticeable relaxation, with almost no daily headaches. My mind remains clear until evening, which greatly enhances my concentration and overall performance.
Read More
10
Improved speech clarity
20 people found this helpful
These are superb pills! A friend ordered them for my child. Following difficult pregnancy and childbirth, the baby had elevated bilirubin, which kills neurons in the brain, causing speech complications. For ages, I couldn't speak as neurologists had no solutions. Taking charge, I searched online and found out about choline and inositol. We tried Now Foods, Choline and Inositol, and a month later, as if a barrier had been removed, he began speaking clearly and constructing sentences. My son is now 5 years old. I highly recommend it! I've ordered more for the entire family to support memory and recover from illness.
Read More
9
Enhanced mental clarity
19 people found this helpful
Great for the brain! Hello everyone! I was searching for dietary supplements to aid my brain since I have to learn vast information. I decided to try Choline with Inositol. The capsules are of a normal size and easy to swallow. I liked the outcome; I take it alongside DMAE from the same manufacturer. My mood is more balanced, sleep is calmer, and my memory functions perfectly. Thank you, IHerb!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 77 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced headaches
224 people found this helpful
This supplement aids in the correct transmission of nerve impulses in the body. Choline and inositol are essential B vitamins necessary for brain, nervous system health, and fatty acid metabolism. I combine these with True Calm and have found noticeable relaxation, with almost no daily headaches. My mind remains clear until evening, which greatly enhances my concentration and overall performance.
Read More
10
Improved speech clarity
20 people found this helpful
These are superb pills! A friend ordered them for my child. Following difficult pregnancy and childbirth, the baby had elevated bilirubin, which kills neurons in the brain, causing speech complications. For ages, I couldn't speak as neurologists had no solutions. Taking charge, I searched online and found out about choline and inositol. We tried Now Foods, Choline and Inositol, and a month later, as if a barrier had been removed, he began speaking clearly and constructing sentences. My son is now 5 years old. I highly recommend it! I've ordered more for the entire family to support memory and recover from illness.
Read More
9
Enhanced mental clarity
19 people found this helpful
Great for the brain! Hello everyone! I was searching for dietary supplements to aid my brain since I have to learn vast information. I decided to try Choline with Inositol. The capsules are of a normal size and easy to swallow. I liked the outcome; I take it alongside DMAE from the same manufacturer. My mood is more balanced, sleep is calmer, and my memory functions perfectly. Thank you, IHerb!
Read More
9
Improved mental cycles
16 people found this helpful
I've been using NOW's choline & inositol for over 10 years. Without it, my quality of life would decline. I deal with anxiety and repetitive thoughts; this supplement breaks that cycle. If I miss a dose, I quickly feel my brain reverting to negative thoughts. However, taking it again calms my mind and helps me regain focus.
Read More
9
Positive body synergy
8 people found this helpful
I am very pleased! Choline and inositol—B4 and B8—are fantastic together in one supplement. They perfectly complement each other, enhancing their beneficial effects on the body, promoting brain activity and lecithin synthesis. Their synergy plays an essential role in healthy cell growth and functionality.
Read More
Frequently Asked Questions
10
Improved speech clarity
20 people found this helpful
These are superb pills! A friend ordered them for my child. Following difficult pregnancy and childbirth, the baby had elevated bilirubin, which kills neurons in the brain, causing speech complications. For ages, I couldn't speak as neurologists had no solutions. Taking charge, I searched online and found out about choline and inositol. We tried Now Foods, Choline and Inositol, and a month later, as if a barrier had been removed, he began speaking clearly and constructing sentences. My son is now 5 years old. I highly recommend it! I've ordered more for the entire family to support memory and recover from illness.
9
Cognitive clarity
1 people found this helpful
After a few weeks of taking NOW Foods Choline & Inositol, I feel the benefits. The capsules are convenient, and this product significantly supports my cognitive function. I have noticed increased clarity and focus throughout the day, along with better stress management. I would highly recommend it for anyone wanting to enhance brain health naturally.
7.5
Cognitive enhancement
25 people found this helpful
Choline and Inositol work well together, and at first, I didn't feel the strong effect I expected. However, within a week, I experienced significant improvements in memory and cognitive abilities—solving intellectual problems became much easier.
7.5
Cycle normalization
276 people found this helpful
Works! An excellent complex from a well-known brand! I originally acquired it to strengthen my nervous system and nerve fibres, but upon learning about its benefits for women's health, I used it for that as well. It helped normalise my cycle, which had been disrupted by severe stress. I took choline-inositol with NAC and Omega 3-6-9, and everything improved. I also bought it for my husband for brain and liver health. I am satisfied with the results and wholeheartedly recommend it.
9
Increased working capacity
1 people found this helpful
An excellent product! My productivity has risen significantly; my brain is now much more responsive to tasks. I've noticed an improvement in my stress resistance and sleep quality, and I recommend this product widely.
9
Improved mental cycles
16 people found this helpful
I've been using NOW's choline & inositol for over 10 years. Without it, my quality of life would decline. I deal with anxiety and repetitive thoughts; this supplement breaks that cycle. If I miss a dose, I quickly feel my brain reverting to negative thoughts. However, taking it again calms my mind and helps me regain focus.
9
Improved cognitive function
3 people found this helpful
I am thoroughly impressed with this supplement. It has become essential in my routine, enhancing my cognitive function and overall brain health. I've noticed improved mental clarity and focus, especially during demanding tasks. Trustworthy brand with exceptional quality.
9
Reduced headaches
224 people found this helpful
This supplement aids in the correct transmission of nerve impulses in the body. Choline and inositol are essential B vitamins necessary for brain, nervous system health, and fatty acid metabolism. I combine these with True Calm and have found noticeable relaxation, with almost no daily headaches. My mind remains clear until evening, which greatly enhances my concentration and overall performance.
9
Enhanced mental clarity
19 people found this helpful
Great for the brain! Hello everyone! I was searching for dietary supplements to aid my brain since I have to learn vast information. I decided to try Choline with Inositol. The capsules are of a normal size and easy to swallow. I liked the outcome; I take it alongside DMAE from the same manufacturer. My mood is more balanced, sleep is calmer, and my memory functions perfectly. Thank you, IHerb!
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
References
- Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, et al. Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. Nat Commun. 2021;12:2148. 10.1038/s41467-021-22379-7
- Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969. 10.1038/onc.2017.208
